In order to develop new antimicrobial agents, a series of Schiff base of Benzimidazole derivative were synthesized and evaluated for their antimicrobial activity. All the synthesized compounds were characterized by IR and 1H-NMR analysis. All compounds exhibited significant antimicrobial activity. The para substituted derivatives were found to be more effective than the ortho substituted derivatives .Compound (VI-d) was found to be the most effective compound against gram positive and negative compounds and also fungi.Compound (VI g and h) were specifically more effective against gram negative bacteria and fungi.
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